Irregular Agents are the Sanctifiers' extermination targets, which they refer to as "Daemons." Generally speaking, Irregular Agents can be categorized into two types: actual viruses and Agents that have developed abnormal behaviors.
Dolls who were forced out of the Neural Cloud Sector do not bear signatures matching the sector they are occupying, which constitutes "abnormal behavior" in the Sanctifiers' book and renders them targets to be hunted down.