Sanctifiers are anti-virus AI programs created by 42Lab to maintain Magrasea's cybersecurity. Operating in a strict hierarchy, they are divided into Greater, Intermediate, and Lesser ranks and obey orders issued by humans with no question.
Greater Sanctifiers are stationed within a surveillance tower known as the Reverse Babylon Tower, overlooking all of Magrasea and keeping it safe. Intermediate Sanctifiers follow commands issued by Greater Sanctifiers in preventing anomalies from occurring within different sectors. Lesser Sanctifiers are not particularly intelligent and would only follow orders issued by Greater and Intermediate Sanctifiers as well as their base commands in purging viral programs that constitute threats to sectors and anomalous Agents.
The Wipe-off Incident has expelled the Dolls' neural clouds from the Neural Cloud Sector, forcing them to enter areas where they do not belong, which causes the Sanctifiers to flag them as Irregular Agents and hunt them down.